You know, I really think that's where the next Iron Man would go, I mean,outside of why not it would make a killing, it's two brilliant scientists yucking it up while tracking down a supervillian.  Give it to Shane Black, throw in an obscure Marvel villain and you're gold.  And it'd really be interesting counter-intuitively because their personalities are rather similar instead of diametrically opposite.

I feel like Joe Pesci might be an interesting person to throw into the mix as well, actually (because I just glanced at "My Cousin Vinnie" on my shelf, NOT Lethal Weapon).

And there's always a BIG name, you know?  Who's the big name, who's this movie's Robert Redford or Michael Douglas?